As I’ve mentioned, NAD+ levels decline with age, with infections, and with all other daily stressors of life. The current working hypothesis is that boosting levels of sirtuins could effectively “mimic” calorie restriction, which obviously would reduce oxidative stress in your cells. Metabolic researchers know that sirtuins decrease this kind of damage by slowing down metabolism. In Super Human, this is one of the hackable “7 pillars of aging” that we know cause aging. The more DNA damage accumulates, the more you get cellular senescence (resulting in the symptoms of aging) and genetic mutations that have been linked to chronic conditions such as cancer. When your metabolism creates more free radicals than your cells can neutralize with their onboard antioxidant defenses, the free radicals cause DNA damage. The more food, or the lower the quality of the food, the more free radicals. When you eat large amounts of food, it combines with oxygen in your cells, which makes free radicals. We do know that NAD+ operates sirtuins, and nicotinamide riboside activates them. That’s why they are a major focus of new healthy aging research. Sirtuins play a key role in regulating our body’s metabolism and cellular health. Stronger Metabolism Equals More Resilience The reason I use Tru Niagen® is that it is clinically proven to raise levels of NAD+, which I already know is a part of my healthy aging program, and now I see evidence that it may support the function of cells when they are stressed. All of those reduce NAD+ levels, and when NAD+ levels are low, cells have a harder time producing and moving the energy they need to function at their best. To use energy to power your defense systems, your body needs an intracellular supply of NAD+ in order to move electrons around.ĭuring quarantine, your body might undergo more stress than it usually does like a poor diet, heavy alcohol consumption, a lack of sleep, and a lack of exercise. Each day we accumulate quadrillions of new mutations in DNA, both from outside attackers like infection and alcohol and from the daily breakdown of food and air known as “metabolism.” Our bodies have powerful defenses to halt and repair this cellular damage that accumulates over time, and all defense and repair systems in your body require energy. NAD+: Essential for Cellular Defense and Repair Although there isn’t yet conclusive research in humans, I’m all over the ways NAD+ functions in cellular defense and repair. That’s why most people now are paying extra attention to ways to support cellular defense. One way I do it is by taking Tru Niagen®, and I have for years now.Īs you might imagine, the first step to living a long time is…not dying. If you read Super Human, my recent New York Times bestseller about how to live for at least 180 years, you’ve already learned some of the reasons you want to keep your NAD+ levels high. How to use NAD+ to Stand Up to Stressors, Starting in the Cells
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